Due to the lack of reports of adverse effects when the Dietary Reference Intakes (DRI) for pantothenic acid were established in 1998, the Food and Nutrition Board of the Institute of Medicine (now the National Academy of Medicine) did not establish a tolerable upper intake level (UL) for pantothenic acid (22)
Therefore, B12 from food or oral supplements will be poorly absorbed if: There is low stomach acid due to use of a Proton Pump Inhibitor (PPI) There is low intrinsic factor
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